MCHC (Mean Corpuscular Hemoglobin Concentration)
MCHC (mean corpuscular hemoglobin concentration) measures the average concentration of hemoglobin within each red blood cell. Unlike MCH (total hemoglobin per cell), MCHC accounts for cell size, expressing hemoglobin as a concentration.
Low MCHC (hypochromic) is a hallmark of iron deficiency — the cells lack sufficient iron to fill with hemoglobin. High MCHC is less common and may indicate spherocytosis (a genetic condition where RBCs are abnormally spherical and concentrated) or cold agglutinins (a lab artifact).
MCHC is the most stable of the red cell indices and is less affected by reticulocyte count or MCV changes, making it a reliable indicator of iron-hemoglobin loading.
What It Measures
Average concentration of hemoglobin within red blood cells, calculated from hemoglobin divided by hematocrit.
Reference Ranges
| Status | Range (g/dL) |
|---|---|
| Optimal | 32–36 g/dL |
| Normal | 31.5–35.5 g/dL |
| Borderline | 30–31.5 g/dL |
| Out of Range | < 30 g/dL or > 37 g/dL |
How GATOR Tracks This
Lab Providers
Related Biomarkers
This content is for informational purposes only and does not constitute medical advice. Reference ranges may vary by laboratory and individual factors. Consult a qualified healthcare provider for interpretation of your results and treatment decisions.
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