Vitamin B6 (Pyridoxine)
Vitamin B6 (pyridoxine) is involved in over 100 enzymatic reactions, primarily in amino acid metabolism, neurotransmitter synthesis (serotonin, dopamine, GABA), and homocysteine metabolism. It works alongside folate and B12 to convert homocysteine to cysteine.
Deficiency can cause neuropathy, depression, confusion, weakened immunity, and elevated homocysteine. Subclinical deficiency is more common than recognized, especially in the elderly, those on certain medications (oral contraceptives, isoniazid), and individuals with high protein intake.
Excessive supplementation (> 200 mg/day chronically) can paradoxically cause sensory neuropathy, so more is not always better.
What It Measures
Plasma pyridoxal 5-phosphate (PLP), the active form of vitamin B6.
Reference Ranges
| Status | Range (nmol/L) |
|---|---|
| Optimal | 20–50 nmol/L |
| Normal | > 20 nmol/L |
| Borderline | 10–20 nmol/L |
| Out of Range | < 10 nmol/L (deficient) |
How GATOR Tracks This
Lab Providers
Related Biomarkers
This content is for informational purposes only and does not constitute medical advice. Reference ranges may vary by laboratory and individual factors. Consult a qualified healthcare provider for interpretation of your results and treatment decisions.
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