Folate (Vitamin B9)
Folate (vitamin B9) is critical for DNA synthesis, cell division, amino acid metabolism, and methylation reactions. It works closely with vitamin B12 to recycle homocysteine back to methionine — deficiency in either vitamin causes homocysteine elevation.
Folate deficiency causes megaloblastic anemia (large, immature red blood cells), fatigue, and cognitive impairment. In pregnancy, adequate folate is essential for preventing neural tube defects. The MTHFR gene variant affects folate metabolism and may require supplementation with methylfolate rather than folic acid.
Serum folate reflects recent intake (days), while red blood cell (RBC) folate reflects longer-term status (months).
What It Measures
Serum concentration of folate (vitamin B9), reflecting recent dietary intake and absorption.
Reference Ranges
| Status | Range (ng/mL) |
|---|---|
| Optimal | > 20 ng/mL |
| Normal | > 5.9 ng/mL |
| Borderline | 3.0–5.9 ng/mL |
| Out of Range | < 3.0 ng/mL (deficient) |
How GATOR Tracks This
Lab Providers
Related Biomarkers
This content is for informational purposes only and does not constitute medical advice. Reference ranges may vary by laboratory and individual factors. Consult a qualified healthcare provider for interpretation of your results and treatment decisions.
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