Lp-PLA2 (Lipoprotein-Associated Phospholipase A2)
Lp-PLA2 (also known as the PLAC test) is an enzyme produced by macrophages within arterial plaque. Unlike hsCRP, which reflects systemic inflammation from any source, Lp-PLA2 is specific to vascular inflammation and actively involved in the atherosclerotic process.
Elevated Lp-PLA2 indicates active inflammation within arterial walls and has been validated as an independent predictor of coronary heart disease and ischemic stroke, even in patients with normal LDL cholesterol. The FDA has cleared it as a cardiovascular risk marker.
Lp-PLA2 is particularly valuable when hsCRP is normal but cardiovascular risk factors persist, as it can identify vascular inflammation that systemic markers miss.
What It Measures
Activity or mass of phospholipase A2 enzyme associated with LDL particles, reflecting vascular-specific inflammation.
Reference Ranges
| Status | Range (ng/mL) |
|---|---|
| Optimal | < 200 ng/mL |
| Normal | < 200 ng/mL |
| Borderline | 200–235 ng/mL |
| Out of Range | > 235 ng/mL |
How GATOR Tracks This
Lab Providers
Related Biomarkers
This content is for informational purposes only and does not constitute medical advice. Reference ranges may vary by laboratory and individual factors. Consult a qualified healthcare provider for interpretation of your results and treatment decisions.
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