Adiponectin
Adiponectin is a protein hormone secreted by adipose (fat) tissue that paradoxically decreases as fat mass increases. Higher adiponectin levels are associated with improved insulin sensitivity, reduced inflammation, and lower cardiovascular risk.
Adiponectin enhances fatty acid oxidation, improves glucose uptake in muscle, reduces hepatic glucose production, and has anti-inflammatory and anti-atherogenic properties. It is one of the few biomarkers where higher levels in overweight individuals predict better metabolic outcomes.
Low adiponectin is associated with insulin resistance, type 2 diabetes, metabolic syndrome, coronary artery disease, and NAFLD. Weight loss, exercise, omega-3 fatty acids, and certain medications (thiazolidinediones) increase adiponectin levels.
What It Measures
Serum adiponectin concentration reflecting metabolic health of adipose tissue and insulin sensitivity.
Reference Ranges
| Status | Range (mcg/mL) |
|---|---|
| Optimal | > 10 mcg/mL |
| Normal | 5–30 mcg/mL (women typically higher than men) |
| Borderline | 3–5 mcg/mL |
| Out of Range | < 3 mcg/mL |
How GATOR Tracks This
Lab Providers
Related Biomarkers
This content is for informational purposes only and does not constitute medical advice. Reference ranges may vary by laboratory and individual factors. Consult a qualified healthcare provider for interpretation of your results and treatment decisions.
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