LDL/HDL Ratio
Formula
LDL-C / HDL-CWhat It Reveals
Atherogenic risk balance between harmful and protective cholesterol fractions.
Interpretation Ranges
Optimal
< 2.0
Favorable cholesterol balance — low atherogenic risk
Borderline
2.0–3.5
Moderate risk — lifestyle optimization recommended
High Risk
> 3.5
Elevated atherogenic risk — intervention warranted
Clinical Significance
The LDL/HDL ratio captures the interplay between atherogenic LDL particles and protective HDL-mediated reverse cholesterol transport. A ratio above 3.5 is associated with a 2–3 fold increase in coronary artery disease risk, independent of total cholesterol.
What To Do
Lower LDL through dietary fiber, plant sterols, and statins if indicated. Raise HDL with regular aerobic exercise, moderate alcohol, and omega-3 fatty acids. Recheck after 3 months of intervention.
Component Biomarkers
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Source: Circulation 2001, Castelli WP; American Heart Association
This content is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare provider for interpretation of your results.