De Ritis Ratio
Formula
AST / ALTWhat It Reveals
Type and severity of liver damage — distinguishes fatty liver from alcoholic liver disease.
Interpretation Ranges
Optimal
0.8–1.2
Normal liver enzyme balance
Borderline
< 0.8
May suggest non-alcoholic fatty liver disease (NAFLD)
High Risk
> 2.0
Suggests alcoholic liver disease or cirrhosis
Clinical Significance
A ratio below 1 suggests NAFLD/NASH. A ratio above 2 strongly suggests alcoholic hepatitis or cirrhosis. Useful for differentiating liver pathology.
What To Do
If elevated: reduce alcohol, lose weight if overweight, check for viral hepatitis. If low with elevated ALT: focus on metabolic health and insulin resistance.
Component Biomarkers
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Source: De Ritis F, Clinica Chimica Acta 1957
This content is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare provider for interpretation of your results.